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In Q4 2021 EARL initiated 18F / 11C Brain PET/CT accreditation. It is based on a pilot study published by Verwer et. al.1 In addition to already active and in good standing either 18F standards 1 or 2 accreditation, for the 18F/11C Brain PET/CT accreditation Hoffman 3D Brain phantom images are required to be submitted once per year. This phantom simulates brain uptake of radiopharmaceuticals with a grey matter to white matter ratio (GMWMr) of 4. The limits of acceptability for the Brain PET/CT accreditation can be reviewed under Accreditation Specifications.
As discussed in the referenced publication, marked differences were found between reconstructions with resolution modeling (PSFON) and those without PSF modeling (PSFOFF). Therefore, separate harmonisation criteria were defined for PSFON and PSFOFF.
Since currently the majority of clinical brain PET scans are reconstructed without PSF (because of the Gibbs artefacts PSF can introduce), the EARL accreditation will focus on PSFOFF reconstructions.
However, we did find that the differences between systems are smaller for PSFON reconstruction (i.e. better harmonisation can be achieved). We will therefore, continue to study the possibilities of harmonisation for PSFON reconstructions and invite sites to (on a voluntary basis) upload PSFON data in addition to the PSFOFF data that is used for accreditation.
1 Harmonisation of PET/CT contrast recovery performance for brain studies. Verwer EE, Golla SSV, Kaalep A, Lubberink M, van Velden FHP, Bettinardi V, Yaqub M, Sera T, Rijnsdorp S, Lammertsma AA, Boellaard R.Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2856-2870. doi: 10.1007/s00259-021-05201-w. Epub 2021 Jan 31.PMID: 33517517